苯丙氨基戊烷(PPAP)
編輯歷史
| 時間 | 作者 | 版本 |
|---|---|---|
| 2017-07-17 16:22 | r2 | |
顯示 diff（91 行未修改）
|
||
| 2017-07-12 07:00 – 07:01 | r0 – r1 | |
顯示 diff+ 苯丙氨基戊烷(PPAP)
+
+ 其實呢...那個中文名稱是google翻譯出來的XD大家幫忙取名吧XDD
+
+ 英文條目:https://en.wikipedia.org/wiki/Phenylpropylaminopentane
+ 中文條目:https://zh.wikipedia.org/wiki/%E8%8B%AF%E4%B8%99%E6%B0%A8%E5%9F%BA%E6%88%8A%E7%83%B7
+
+ Phenylpropylaminopentane
+ (-)-1-Phenyl-2-propylaminopentane (also known as (-)-PPAP and N,α-dipropylphenethylamine)[1][2][3] is a stimulant of the phenethylamine and amphetamine classes with an unusual effects profile and mechanism of action.[4]
+
+ '''1-苯基-2-丙基氨基戊烷'''(又稱為'''N,α-二丙基苯乙胺'''，簡稱'''PPAP''')<ref>{{cite web | url=http://www.google.de/patents/US5220068 | title=Patent US 5220068 - Psychostimulant agent | date=15 June 1993 | author=Jozsef Knoll}}</ref><ref>{{cite web | url=http://www.google.de/patents/US6214859 | title=Patent US 6214859 - Ethylamine derivatives | date=10 April 2001 | author=Fumio Yoneda}}</ref><ref>{{cite web | url=http://www.google.de/patents/US5075338 | title=Patent US 5075338 - Method of treatment of learning deficiency | date=24 December 2001 | author=Jozsef Knoll}}</ref>，是[[苯乙胺]]及[[安非他命]]類的[[興奮劑]]，具有特殊的作用機制及效果<ref>{{cite journal | url=http://www.ncbi.nlm.nih.gov/pubmed/1356324 | title=The pharmacology of 1-phenyl-2-propylamino-pentane (PPAP), a deprenyl-derived new spectrum psychostimulant. |vauthors=Knoll J, Knoll B, Török Z, Timár J, Yasar S | journal=Archives internationales de Pharmacodynamie et de Thérapie | date=March–April 1992 | issue=316 | pages=5–29 | pmid=1356324}}</ref>。
+
+
+
+
+ (-)-PPAP is classified as a monoaminergic activity enhancer that stimulates the impulse propagation mediated transmitter release of the neurotransmitters dopamine, norepinephrine and serotonin in the brain.
+
+ 苯丙氨基戊烷屬於[[單胺類神經遞質]]活動的増效劑。此類増效劑可刺激腦中衝動介導的遞質釋放（[[多巴胺]]、[[腎上腺素]]、[[血清素]]）。
+ *感覺漏掉一小段
+ *可以補
+ *苯丙氨基戊烷屬於單胺類(單胺能)神經傳導增效劑，其可刺激衝動傳導造成的神經遞質釋放。
+
+ Unlike stimulants such as amphetamine, which release a flood of monoamine neurotransmitters in an uncontrolled manner, (-)-PPAP instead only increases the amount of neurotransmitters that get released when a neuron is stimulated by receiving an impulse from a neighbouring neuron.
+
+ 安非他命這類興奮劑會促進大量神經遞質釋出。苯丙氨基戊烷只有在[[神經元]]受鄰近神經元刺激時才會增加神經遞質的釋出量。
+
+ *整體文意感覺起來是苯丙氨基戊烷不會一次釋出可能導致整體狀況失控的大量神經傳導物質
+ *但還是覺得˙有哪裡怪怪的，樓下你怎麼看?把失控式拿掉?
+ *個人看法是這段字(release a flood of monoamine neurotransmitters in an uncontrolled manner)主要是說安非他命獨立於刺激提升突觸傳導物濃度，用來對比PPAP的作用模式 。原文我覺得就有點戲劇化了
+ *這倒是真的，但是安非他命只有在部分腦域促進某些神經傳導物質的濃度提升，如果修改為"苯丙氨基戊烷不會一次釋出大量神經傳導物質，而是只有在[[神經元]]受鄰近的其他神經元刺激時，才會增加神經傳導物的釋出量。"這樣如何?(還是覺得uncontrolled manner是指導致出現超乎我們能控制的狀態，例如過度亢奮等
+ *我覺得這是對苯丙胺作用認知上的差別，因為我對它的作用的想像就是穩定的提升突觸傳導物濃度
+ *，所以覺得一次釋放出大量怪怪的
+ *我是剛剛看安非他命的藥動，他的確會導致一口氣大量傳遞物質釋出，量大到會失控的那種
+ *治療用劑量也會?
+ *治療劑量非常低量，但是也很少再使用了有成癮性阿
+ *最快方式就把失控性移除，他需要補充更多但書才能放在上面
+ *嗯
+
+
+
+
+
+ *可是安非他命也不會失控式
+ *那個uncontroll是個形容量很大，a flood of = 像山洪爆發般
+ *安非他命會直接反轉DAT NET 穩定的提高突觸傳導物濃度，PPAP則是對外界刺激的反應提高
+ *所以我覺得失控式一次釋出大量 這樣說法有點加味太多
+ *或者可能原文就有些問題？
+ *直接看ref最準
+ *ref沒有copy進來 XD
+ *第五個XDhttp://www.sciencedirect.com/science/article/pii/0024320596000148
+ *盜版一下 http://sci-hub.cc/10.1016/0024-3205(96)00014-8
+ *戰鬥民族的站！
+ *超好用
+ *覺得我翻完後會從此不聽PPAP QAQ
+ *我辨識不出相關句子，我閃開交給專業的去
+ *我覺得你翻的對ㄟ其實，不要離開阿QAQ
+ *我是先去看別的句子啦 (p.s 後半句好像-似乎-可能也是指量，指量只能剛好影響鄰近的神經元之類的)
+ *接收周圍神經元的刺激吧(好煩阿阿
+ *
+
+ Both amphetamine and (-)-PPAP promote the release of monoamines,
+ however while amphetamine causes neurons to dump neurotransmitter stores into the synapse regardless of external input,(-)-PPAP does not influence the pattern of neurotransmitter release and instead releases a larger amount of neurotransmitters than normal.[5]
+
+ 苯丙氨基戊烷及安非他命皆會促進單胺類的釋放。然而不論有無外界刺激，安非他命都會使神經元將庫存神經傳遞物質運往[[突觸]]；苯丙氨基戊烷則是在不改變神經遞質釋放模式的情況下，釋放出比正常量更多的神經傳遞物質.<ref>{{cite journal | url=http://www.sciencedirect.com/science/article/pii/0024320596000148 | title=(−)Deprenyl and (−)1-phenyl-2-propylaminopentane, [(−) PPAP] act primarily as potent stimulants of action potential — transmitter release coupling in the catecholaminergic neurons |author1=Joseph Knoll |author2=Ildikó Miklya |author3=Berta Knoll |author4=Raissa Markó |author5=Károly Kelemen | journal=Life Sciences | date=February 1996 | volume=58 | issue=10 | pages=817–827 | doi=10.1016/0024-3205(96)00014-8 | pmid=8602114}}</ref>
+ 。‧
+ *那種--A(b)--的就是我不確定怎麼翻
+ *能翻多少就翻多少吧~我們會幫忙微調校稿的
+ *
+
+
+ (-)-PPAP has no monoamine oxidase inhibitory activity.[6]
+ 苯丙胺基戊烷不抑制單胺氧化酶<ref>{{cite journal | url=http://onlinelibrary.wiley.com/doi/10.1002/cbf.1183/abstract | title=Acute and delayed effect of (−) deprenyl and (−) 1-phenyl-2-propylaminopentane (PPAP) on the serotonin content of peritoneal cells (white blood cells and mast cells) |author1=G. Csaba |author2=P. Kovács |author3=Éva Pállinger | journal=Cell Biochemistry and Function | date=January–February 2006 | volume=24 | issue=1 | pages=49–53 | doi=10.1002/cbf.1183 | pmid=15584092}}</ref>
+ 。
+ *改成"PPAP不抑制單胺氧化酶"怎麼樣?
+ *好喔
+
+
+ *See also[編輯原始碼]
+ *(-)-BPAP
+ *MBDP
+ *Pentedrone
+ *
+ *References[編輯原始碼]
+ *1. Jozsef Knoll (15 June 1993). "Patent US 5220068 - Psychostimulant agent".
+ *2.Fumio Yoneda (10 April 2001). "Patent US 6214859 - Ethylamine derivatives".
+ *3. Jozsef Knoll (24 December 2001). "Patent US 5075338 - Method of treatment of learning deficiency".
+ *4. Knoll J, Knoll B, Török Z, Timár J, Yasar S (March–April 1992). "The pharmacology of 1-phenyl-2-propylamino-pentane (PPAP), a deprenyl-derived new spectrum psychostimulant.". Archives internationales de Pharmacodynamie et de Thérapie (316): 5–29. PMID 1356324.
+ *5.Joseph Knoll; Ildikó Miklya; Berta Knoll; Raissa Markó; Károly Kelemen (February 1996). "(−)Deprenyl and (−)1-phenyl-2-propylaminopentane, [(−) PPAP] act primarily as potent stimulants of action potential — transmitter release coupling in the catecholaminergic neurons". Life Sciences. 58 (10): 817–827. doi:10.1016/0024-3205(96)00014-8. PMID 8602114.
+ *6.G. Csaba; P. Kovács; Éva Pállinger (January–February 2006). "Acute and delayed effect of (−) deprenyl and (−) 1-phenyl-2-propylaminopentane (PPAP) on the serotonin content of peritoneal cells (white blood cells and mast cells)". Cell Biochemistry and Function. 24 (1): 49–53. doi:10.1002/cbf.1183. PMID 15584092.
+ 2016/9/30 整合至維基百科上
|
||