阿托品(Atropine)

英文引言:https://en.wikipedia.org/wiki/Wikipedia:WikiProject_Medicine/Translation_task_force/RTT/Simple_atropine 

中文:https://zh.wikipedia.org/zh/%E9%98%BF%E6%89%98%E5%93%81 

(原中文引言)

阿托品(英語:Atropine)是一種M蕈毒鹼受器阻斷藥,能可逆地阻礙乙醯蕈毒鹼M蕈毒鹼受器(Muscarinic receptor)結合。它存在於顛茄天仙子曼陀羅莨菪茄科植物中,左旋莨菪鹼為天然構型,經提取處理後得到的消旋莨菪鹼即為阿托品。[1]

Atropine is a medication used to treat certain types of nerve agent and pesticide poisonings, some types of slow heart rate(心跳过缓), and to decrease saliva production during surgery.[3] It is typically given intravenously(靜脈注射) or by injection into a muscle.[3] Eye drops are also available which are used to treat uveitis and early amblyopia(弱視).[4] The intravenous solution usually begins working within a minute and lasts half an hour to an hour.[1] Large doses may be required to treat poisonings.[3]

’’’阿托品’’’({{lang|en|Atropine}}),又稱’’’阿托平’’’。是一種用來治療[[神經毒氣]]或[[殺蟲劑中毒]]的藥物,也用在某些[[心跳過緩]],與手術時減少唾液分泌用[3]。一般為靜脈注射或肌肉注射用[3]。眼藥水劑型使用於治療{{le|葡萄膜炎|uveritis}}與早期[[弱視]]。靜脈注射劑型的藥物,在一分鐘內就會生效,並持續半小時到一小時左右[1]。治療中毒,可能需要較大劑量的藥物[3]。

Common side effects(副作用) include a dry mouth, large pupils, urinary retention(尿瀦留), constipation, and a fast heart rate(心跳过速). It should generally not be used in people with glaucoma(青光眼).[3] While there is no evidence that its use during pregnancy causes birth defects(先天性障碍), it has not been well studied. It is likely safe during breastfeeding.[5] It is an antimuscarinic(3) (also known as an anticholinergic) that works by inhibiting the parasympathetic nervous system(副交感神经).[3]

阿托品是一種{{le|蕈毒鹼受器阻斷藥|Antimuscarinic}},可以抑制[[副交感神經]]。常見[[副作用]]包含口乾、{{le|散瞳|Mydriasis|瞳孔放大}}、[[尿瀦留]]、便祕,以及[[心跳過速]]。[[青光眼]]患者如非必要請勿使用[3]。目前顯示哺乳期使用是安全的[5]。尚無證據孕婦使用阿托品會導致新生兒[[先天性障礙]],相關研究仍待進行。

Atropine occurs naturally in a number of plants of the nightshade family(茄科) including deadly nightshade(颠茄), Jimson weed(曼陀罗花), and mandrake(茄参).[6] It was first isolated in 1833.[7] Atropine is on the WHO Model List of Essential Medicines(世界卫生组织基本药物标准清单), the most important medications needed in a basic health system(13).[8] It is available as a generic medication(通用名药物) and not very expensive.[3][9] A one-milligram vial costs wholesale between 0.06 and 0.44 USD.[10]

阿托品存在於數種[[茄科]]植物體內,如[[顛茄]]、[[天仙子]]、[[曼陀羅]]及[[茄參]]等[6]。於1833年首次被分離出來[7]。阿托品列名於[[世界卫生组织基本药物标准清单]],為基礎醫療體系必備藥物之一。該藥物屬於[[通用名藥物]],且價格低廉[3][9]。每毫克的批發價價格區間約在0.06到0.44美金之間[10]。

2016/3/19 已整合到中文條目中