卵巢癌/Ovarian cancer

https://en.wikipedia.org/wiki/Wikipedia:WikiProject_Medicine/Translation_task_force/RTT/Simple_Ovarian_cancer 

原本中文條目內容:

卵巢癌是指女性卵巢癌症,發病年齡平均約50歲,患者多為老年女性。患者初期並沒有明顯病徵,只是腹部會略為肥胖,有腹脹之感,進食之後可能會腸胃不適。當病情到了後期時,便會出現腹部積水。

{{Infobox disease

| Name           = 卵巢癌(人類)

| ICD10          = {{ICD10|C|56||c|51}}

| ICD9           = {{ICD9|183}}, {{ICD9|220}}

| ICDO           = varied

| Image          = mucinous_lmp_ovarian_tumour_intermed_mag.jpg

| Caption        = [[Micrograph]] of a mucinous ovarian carcinoma

| OMIM           =

| OMIM_mult      =

| MedlinePlus    = 000889

| eMedicineSubj  = med

| eMedicineTopic = 1698

| DiseasesDB     = 9418

| MeshID         = D010051

}}

<!-- 定義及症狀 -->

’’’卵巢癌’’’是發源自女性[[卵巢]]的[[癌症]][1],會產生可入侵及[[遠端轉移|轉移]]]到其他部位的異常[[細胞]][2]。卵巢癌初期症狀不明顯,隨病情進展,才會出現許多癌症的典型症狀,包括脹氣丶腹脹丶[[骨盆痛]]等[3]。癌症較容易擴散到[[腹膜]]、[[淋巴結]]丶[[肺臟]]丶[[肝臟]]等部位[[4]]。

<!-- Definition and Symptoms -->

Ovarian cancer is a cancer that begins in an ovary.[1] It results in abnormal cells that have the ability to invade or spread to other parts of the body.[2]  Early in this process, symptoms may be vague or not apparent, though  they become more likely as the cancer progresses. Symptoms may include  bloating, pelvic pain, and abdominal swelling, among others.[3] Common areas where the cancer may spread include the lining of the abdomen, lymph nodes, lungs, and liver.[4]

<!-- Cause and Diagnosis -->

The risk of ovarian cancer is higher in people who ovulate more. Thus, those who have never had children are at increased risk, as are those who begin ovulation at a younger age or reach menopause at an older age.[5] Other risk factors include hormone therapy after menopause, fertility medication, and obesity.[1][6] Factors that decrease risk include hormonal birth control, tubal ligation, and breast feeding.[6] About 10% of cases are related to inherited genetic risk, and those with the gene mutations BRCA1 or BRCA2  have about a 50% chance of developing the disease. The most common type  of ovarian cancer, comprising more than 95% of cases, is ovarian carcinoma. Five main subtypes of ovarian carcinoma occur, of which  high-grade serous is most common. These tumors are believed to start in  the cells covering the ovaries,[5] though some may form from the Fallopian tubes.[7] Less common types include germ cell tumors and sex cord stromal tumors.[5] The diagnosis is confirmed by examination of a biopsy usually removed during surgery.[3]

<!-- 成因及診斷 -->

[[排卵]]越多的人,罹患卵巢癌的機率也會變高。所以從未產子的、較早開始排卵的,或是較晚進入更年期的人,罹患的機率都會上升[5]。其他危險因子包括[[更年期|停經]]後的{{en-link|荷爾蒙治療|hormone therapy}}、{{en-link|排卵藥物|fertility medication}},和[[肥胖症]]等等[1][6]。降低風險的方法則包括{{en-link|荷爾蒙避孕法|Hormonal contraception}}、{{link-en|輸卵管結紮術|Tubal ligation}},以及[[母乳餵養|哺乳]]等[6]。大約有1成的病例是來自遺傳風險,而{{link-en|BRCA1}}或{{link-en|BRCA2}}基因突變者,有將近一半的機會誘發此症。卵巢癌中最常見的類型是卵巢上皮細胞癌 ({{lang-en|ovarian carcinoma}}),高達95%的病例都屬於此類型。卵巢上皮細胞癌包含了五種亞型,其中高分化漿液性({{lang-en|high-grade serous}})卵巢癌是最常見的。一般認為這些腫瘤是來自卵巢表面的細胞[5],不過有些可能是在[[輸卵管]]形成[7]。比較罕見的類型則有[[生殖細胞瘤]]和[[性索基質腫瘤]][5]。要確診是哪一種類型,通常是透過對手術中移除的部分做活體切片檢察[3]。

<!-- Prevention, Treatment and Prognosis -->

Screening is not recommended in women who are at average risk, as  evidence does not support a reduction in death and the high rate of  false positive tests leads to unneeded surgery with its own risks.[8] Those at very high risk may have their ovaries removed as a preventive measure.[1]  If caught and treated in an early stage, ovarian cancer may be curable.  Treatments usually include some combination of surgery, radiation therapy, or chemotherapy.[3] Outcomes depends on the extent of the disease and the subtype of cancer present.[5] The overall five-year survival rate in the United States is 45%.[9] Outcomes are worse in the developing world.[5]

<!--預防, 治療及癒後-->

一般健康女性不建議進行卵巢癌筛查,因為證據並未顯示卵巢癌筛查能降低死亡率,而且假陽性的比例高,會造成不必要的手術,而且手術本身也有其風險[8]。若是罹患卵巢癌風險非常高的女性,可以切除卵巢以避免罹患卵巢癌[1]。若在卵巢癌的早期就發現並加以治療,卵巢癌是可以治癒的[3],治療方式一般包括手術、[[放射線療法]]及[[化學療法]][3],結果視疾病的程度及卵巢癌的類型而定[5]。卵巢癌在美國的[[五年存活率]]為45%[9]。在開發中國家的存活率較低[5]。

<!-- Epidemiology -->

In 2012, ovarian cancer occurred in 239,000 women and resulted in  152,000 deaths worldwide. This made it the seventh-most common cancer  and the eighth-most common cause of death from cancer in women. It is  more common in North America and Europe than Africa and Asia.[5]

<!-- 流行病學 -->

2012年全世界共有23萬9千名女性罹患卵巢癌,造成15萬2千人死亡。是癌症中罹患人數第七多的癌症,也是造成女性死亡癌症中的第八位。卵巢癌在北美洲及歐洲較盛行,比在非洲及亞洲要常見[5]。

2015-09-26 已整合到中文維基百科「卵巢癌 」的引言頁面

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