美服培酮(RU-486)

英文條目:https://en.wikipedia.org/wiki/Wikipedia:WikiProject_Medicine/Translation_task_force/RTT/Simple_Mifepristone

中文條目:https://zh.wikipedia.org/wiki/%E7%BE%8E%E6%9C%8D%E5%9F%B9%E9%85%AE

原始中文引言可參酌使用

米非司酮(Mifepristone,俗稱RU486),為黃體素拮抗劑,會競爭母體內黃體素的接受器,使母體黃體素無法作用在應作用的接受器上,導致母體子宮肌收縮,胚胎隨著子宮內膜自然崩落,以達到人工流產目的。常用作墮胎藥,依台灣衛生署適用於懷孕前期(小於七週)子宮內孕之人工流產[1],也作為避孕藥使用,商品名:Mifegyne、Mifeprex。

Mifepristone (or RU-486) is a medication typically used with misoprostol to bring about an abortion.[1] This combination is more than 95% effective during the first 50 days of pregnancy. It is also effective in the second trimester of pregnancy.[2][3] Two weeks after use effectiveness should be verified. It is taken by mouth.[1]

’’’美服培酮’’’ (Mifepristone,又稱 RU-486))是一種藥物,常與{{en|米索前列醇}}併用以造成[[流產]] .[1] 。這種配方在[[妊宸|懷孕]]前50天有95%的成功率,在[[妊娠#懷孕中期|懷孕中期]]也相當有效 [2][3]。在施藥後兩週需要追蹤以確認效果。這個藥物是口服的 .[1]

Common side effects include abdominal pain, feeling tired, and vaginal bleeding. Serious side effects may include heavy vaginal bleeding, bacterial infection, a malformed baby if the pregnancy does not ended. If used appropriate follow up care needs to be available. It works by blocking the effects of progesterone. and causing contractions of the uterus.[1]

常見的副作用包含腹痛、疲倦和陰道出血。嚴重的副作用可能有大量陰道出血、細菌感染和妊娠未中止的胎兒畸形。使用後需要有適當的後續追蹤及照護。它作用的機轉是拮抗[[前列腺素]]的作用,並造成子宮收縮 .[1]

Mifepristone was developed in 1980 and come into use in France in 1987.[4] It became available in the United States in 2000.[2] It is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system.[5] As of 2014 it is not easily available in either Canada or Australia.[6] Cost and availability limits access in many parts of the developing world.[7][8] In the United States it costs more than 200 USD a dose.[9]

美服培酮開發於1980年,1987年法國開始使用此款藥品[4],美國則在2000年時核准美服培酮的上市[2]。美服培酮為[[世界衛生組織基本藥物標準清單]]內的藥物,同時更為[[基礎醫療系統]]內的重要必須藥品[5] 。時至2014年,在加拿大或澳洲它的取得依然不易[6] ,在部分開發中國家美服培酮的成本與獲取仍舊受到許多限制[7][8]。單劑美服培酮在美國當地的售價更超過200美元[9]