https://en.wikipedia.org/wiki/Wikipedia:WikiProject_Medicine/Translation_task_force/RTT/Simple_TMPSMX
Trimethoprim/sulfamethoxazole (TMP/SMX), also known as co-trimoxazole among other names, is an antibiotic(抗细菌药) used to treat a variety of bacterial infections(病原细菌).[1] It consists of one part trimethoprim(甲氧苄啶) to five parts sulfamethoxazole(磺胺甲噁唑).[2] It is used for urinary tract infections(泌尿道感染), MRSA(耐甲氧西林金黄色葡萄球菌) skin infections, travelers’ diarrhea(旅行者腹瀉), respiratory tract infections, and cholera(霍亂), among others.[1][2] It may be used both to treat and prevent pneumocystis carinii pneumonia(肺囊蟲肺炎) in people with HIV/AIDS(艾滋病). It can be given by mouth or intravenously.[1]
撲菌特(Trimethoprim/sulfamethoxazole, TMP/SMX)，較為人知的名稱是磺胺劑(co-trimoxazole)，係為一種antibiotic(抗细菌药)用以治療各種bacterial infections(病原细菌)感染。[1] 撲菌特包含一種trimethoprim(甲氧苄啶)到五種sulfamethoxazole(磺胺甲噁唑)[2]，用途是治療urinary tract infections(泌尿道感染)、MRSA(耐甲氧西林金黄色葡萄球菌)皮膚感染、 travelers’ diarrhea(旅行者腹瀉)、呼吸道感染(respiratory tract infections)以及cholera(霍亂)等病症。[1][2]撲菌特既可用於預防，亦可用於治療HIV/AIDS(艾滋病)患者的pneumocystis carinii pneumonia(肺囊蟲肺炎)；投藥方式有口服或注射至靜脈。[1]
Common side effects include nausea(恶心), vomiting(呕吐), rash(疹), and diarrhea(腹瀉). Severe allergic reactions(过敏) and Clostridium difficile diarrhea(偽膜性結腸炎) may occasionally occur. Its use near the end of pregnancy(妊娠) is not recommended.[1] It appears to be okay during breastfeeding(母乳餵養) as long as the baby is healthy.[3] TMP/SMX generally results in bacterial death. It works by stopping the metabolism of folate.[1]
常見的副作用包含nausea(恶心)、vomiting(呕吐)、引起rash(疹)及diarrhea(腹瀉)。也可能發生嚴重的allergic reactions(过敏)反應與Clostridium difficile diarrhea(偽膜性結腸炎)；不建議在pregnancy(妊娠)晚期患者身上投用此藥，然而在寶寶健全的情況下，讓breastfeeding(母乳餵養)患者服用似乎是無虞的。撲菌特藉由停止葉酸的新成代謝( stopping the metabolism of folate)以造成細菌死亡。[1]
TMP/SMX was first sold in 1974.[4] It is on the World Health Organization’s List of Essential Medicines(世界卫生组织基本药物标准清单), the most important medications needed in a basic health system.[5] It is available as a generic medication(通用名药物) and is not very expensive.[2] In the United States it is about 0.40 USD per dose.[1]
撲菌特上市於1974年[4] ，在最基本的健康照護系統(health system)中最必要的藥物清單[[世界卫生组织基本药物标准清单]]登錄有案[5] ，作為generic medication(通用名药物)也不是非常昂貴.[2]，在美國，一劑撲菌特的定價大約在0.40美元左右。[1]