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Saquinavir, sold under the brand names Invirase and Fortovase, is an antiretroviral drug(抗反轉錄病毒藥物) used together with other medications to treat or prevent HIV/AIDS(艾滋病).[1] Typically it is used with ritonavir or lopinavir/ritonavir(快利佳). It is taken by mouth.[1]
’’’沙奎那維’’’（{{lang|en|saquinavir}}），商品名’’’Invirase’’’和’’’Fortovase’’’，為一種[[抗反轉錄病毒藥物]]，可與其他藥物合併治療[[愛滋病]][1]。通常會與{{le|ritonavir|ritonavir}}或[[快利佳]]合併使用，該藥屬於口服藥物[1]。
Common side effects include nausea, vomiting, diarrhea, and feeling tired. More serious side effects include problems with QT prolongation(長QT症), heart block, high blood lipids(高脂血症), and liver problems. It appears to be safe in pregnancy. It is in the protease inhibitor(蛋白酶抑制剂) class and works by blocking the HIV protease.[1]
常見副作用包和噁心、嘔吐、腹瀉，以及疲憊。嚴重副作用則包含[[長QT症]]、{{le|心阻斷|Heart block}}、[[高脂血症]]，以及肝臟問題。妊娠期間用藥目前顯示安全。本藥物屬於[[蛋白酶抑制劑]]，可抑制{{le|HIV蛋白酶|HIV protease}}的作用[1]。
Saquinavir was first sold in 1995.[2] It is on the World Health Organization’s List of Essential Medicines(世界卫生组织基本药物标准清单), the most important medication needed in a basic health system.[3] As of 2015 it is not available as a generic medication(通用名药物) and is expensive.[4] The wholesale cost is about 4.50 USD per day.[5]
沙奎那維於1995年首次上市[2]，並列名於[[世界卫生组织基本药物标准清单]]之中，為基礎公衛體系必備藥物之一[3]。本品迄今仍非[[學名藥]]，因此價格相當昂貴[4]，一日劑量的批發價約為4.50美金左右[5]。