脊髓灰質炎

英文引言:https://en.wikipedia.org/wiki/Wikipedia:WikiProject_Medicine/Translation_task_force/RTT/Simple_polio

中文條目:https://zh.wikipedia.org/wiki/%E8%84%8A%E9%AB%93%E7%81%B0%E8%B3%AA%E7%82%8E

(原中文引言,歡迎參酌引用)

並感染脊髓神經灰白質。數日間可引致麻痺,以致殘廢,嚴重者可致死亡。這個病症通常為五歲以下之兒童被感染,現已有脊髓灰質炎疫苗預防

1954年,科學家喬納斯·索爾克即發明了注射式疫苗;1955年,波蘭裔的病毒學家阿爾伯特·沙賓以減毒的活病毒製造出了小兒麻痺口服疫苗(OPV)[1]並被廣泛使用。但因口服糖丸中含有活病毒,有極低比例兒童(據統計約75萬分之一[2])可能因服用糖丸反而感染病毒並導致嚴重不良反應[3],因此世界衛生組織已經要求世界各國逐漸使用注射接種的滅活脊灰疫苗(IPV)取代口服脊灰減毒活疫苗(OPV),以達到在2018年全球消滅脊髓灰質炎的目標[4][5]

感染小兒麻痹症的患者,大概有10%會導致病毒侵入神經系統,從而造成小兒麻痹症後遺症

Poliomyelitis, often called polio or infantile paralysis, is an infectious disease caused by the poliovirus. Approximately 90% to 95% of infections cause no symptoms.[1] Another 5 to 10% of people have minor symptoms such as: fever, headache, vomiting, diarrhea, neck stiffness and pains in the arms and legs.[1][2] These people are usually back to normal within one or two weeks. In about 0.5% of cases there is muscle weakness resulting in an inability to move.[1] This can occur over a few hours to few days.[1][2]The weakness most often involves the legs but may less commonly involve the muscles of the head, neck and diaphragm. Many but not all people fully recover. In those with muscle weakness about 2% to 5% of children and 15% to 30% of adults die.[1] Years after recovery post-polio syndrome may occur, with a slow development of muscle weakness similar to what the person had during the initial infection.[3]

小兒麻痺症(英語:Poliomyelitis、Polio;小児麻痺,取自日語)又譯急性灰白髓炎脊髓灰質炎。是由脊髓灰質炎病毒引起,可感染人類病症。大約有90%到95%的感染並[[沒有任何症狀]][1]。剩下5%到10%有發燒、[[頭痛]]、嘔吐、腹瀉、頸部僵硬以及四肢疼痛等輕微症狀[1][2]。這些有症狀的患者往往在一到兩周內就會完全復原。只有約0.5%的患者會發生[[肌力變弱]]而導致[[行動困難]][1]。疾病的進程可能只是數小時,也可能需要數天[1][2]。肌力變弱的狀況往往發生在下肢,很少發生在頭部、頸部、[[橫膈膜]]的肌肉。大多數的人可以自行復原,但少數的人會造成終生殘疾。感染此病毒造成肌力變弱的患者中,有2%到5%的幼年患者與15%到30%成年患者會導致死亡[1]。從[[後小兒麻痺感染症候群]]中恢復,需要很長的時間,會很長一段時間都有如同感染時期一樣的肌力不足[3]。

Poliovirus is usually spread from person to person through infected feces entering the mouth.[1] It may also be spread by food or water containing human feces and less commonly from infected saliva.[1][2] Those who are infected may spread the disease even if no symptoms are present for up to six weeks. The disease may be diagnosed by finding the virus in the feces or detecting antibodies against it in the blood.[1]

小兒麻痺病毒通常經[[糞口傳播]][1]。也有可能經由被糞便汙染的水或食物傳染,經由[[唾液]]傳染是較為少見的狀況[1][2]。感染病毒的患者,即便已經毫無症狀達六周,還是有可能具有散播疾病的能力。藉由在患者的[[糞便]]之中找到病毒,或是在血液中找到相對應的[[抗體]],可以用來作為小兒痲痹症的診斷依據[1]。

The disease is preventable with the polio vaccine; however, a number of doses are required for it to be effective.[2] The United States Center for Disease Control recommends polio vaccination boosters for travelers and those who live in countries where the disease is occurring.[4] Once infected there is no specific treatment.[2] In 2013 polio affected 416 people down from 350,000 cases in 1988.[2] In 2014 the disease was only spreading between people in Afghanistan, Nigeria, and Pakistan.[2]

小兒痲痺症是可以藉著施打[[小兒痲痺疫苗]]來預防感染的,但為了讓疫苗達到效用,必須連續注射多劑才行[2]。美國疾病管制局建議旅客還有居住在小兒痲痺病毒依然猖獗的國家之居民,應追加注射小兒痲痺疫苗[4] 。一旦感染後,目前尚無特效藥或療法[2] 。小兒痲痺的感染人數,已從1988年的350000例,降至2013年的416例[2] 。在2014年,此疾病只在[[阿富汗]]、[[奈及利亞]]與[[巴基斯坦]]間傳播[2]

Poliomyelitis has existed for thousands of years, with depictions of the disease in ancient art.[1] The disease was first recognized as a distinct condition by Michael Underwood in 1789[1] and the virus that causes it was first identified in 1908 by Karl Landsteiner.[5]Major outbreaks started to occur in the late 19th century in Europe and the United States.[1] In the 20th century it became one of the most concerning childhood diseases in these areas.[6] The first polio vaccine was developed in the 1950s by Jonas Salk.[7] It is hoped that vaccination efforts and early detection of cases will result in global eradication of the disease by 2018.[8] In 2013; however, there were reports of new cases in Syria[9] and in May 2014, the World Health Organization declared a public health emergency of international concern due to the outbreaks of disease in Asia, Africa and the Middle East.[10] The disease does not occur in any other animals.[1]

小兒痲痺症已存在有千年之久,在古代的藝術品中,處處可見對此病症的描寫[1] 。在1789年,英國醫師{{le|麥可·安德伍德|Michael Underwood}}首先對小兒痲痺症提出完整的臨床描述[1] ,接著再1908年,奧地利裔醫師[[蘭德施泰納]]是第一個確定脊髓灰質炎病毒的人[5]。大規模的疾病爆發始於19世紀末的歐洲與美國[1] 。20世紀,小兒痲痺症更接著成為疫區中最讓人擔憂的[[幼童疾病]][6] 。1950年代,美國病毒學家沙克製作出世上第一劑小兒痲痺疫苗[7] 。期盼藉由[[疫苗的施打]]和早期發現,使我們最終可於2018年將這個疾病自世界上根除[8] 。在2013年,卻在[[敘利亞]]發現幾例新個案[9],且2014年五月,[[世界衛生組織]]因為小兒痲痺症在亞洲、非洲以及中東的疫情爆發所以發佈[[國際公共衛生緊急事件]][10] 。到今天為止,在其他動物上並未發現感染小兒痲痺症的情形[1]

2016/3/4 已整合到中文維基

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